-Scope 1+2 CO2 emissions: 40% reduction by 2025 (Base year 2019) -Scope 1+2 CO2 emissions: 60-75% reduction by 2030 (Base year 2019) -Scope 1+2 CO2 emissions: Zero emissions by 2050 (Base year 2019) -Scope 3 CO2 emissions: 30% reduction by 2030 (Base year 2019)

-Scope 1+2 energy consumption: 5% reduction by 2025 (Base year 2019) -Scope 1+2 energy consumption: 15% reduction by 2030 (Base year 2019) -Sustainable electricity ratio: 100% by 2025 (Base year 2019)

-Industrial waste reduction: 5% reduction by 2025 (Base year 2019) -Industrial waste reduction: 10% reduction by 2030 (Base year 2019) -Plastic waste reduction: 5% reduction by 2025 (Base year 2019) -Plastic waste reduction: 10% reduction by 2030 (Base year 2019) -Water resource conservation (water withdrawal): 15% reduction by 2030 (Base year 2019) -Hazardous waste reduction: 5% reduction by 2025 (Base year 2019) -Hazardous waste reduction: 10% reduction by 2030 (Base year 2019) -Fluorocarbon Usage: We will apply facility renewal plans to business plans and aim to achieve 25% reductions in 2025 and 100% reductions in 2030 compared to 2020

-Once a year: Management: Chugai Code of Practice Guidelines for Provision of Sales Information on Prescription Drugs Fair Competition Code: Knowledge necessary for management -Once a year: All employees of Chugai Group: Chugai Code of Practice Guidelines for Provision of Sales Information on Prescription Drugs Fair Competition Code: Knowledge for appropriate interaction with healthcare professionals, etc. and provision of information -Once a year: Compliance Officer: Chugai Code of Practice Guidelines for Provision of Sales Information on Prescription Drugs Fair Competition Code: Knowledge necessary to promote compliance in each department -2030: Degree of shared understanding of our Core Values: 100%

-2030: Job-fill rate for highly specialized human resources (Job-fill rate for science specialists/digital specialists/ medical doctors): 90% -2030: Job-fill rate for global human resources in key positions: 100% -2030: Human resource development investment (per person) and I Learning utilization rate: Investment: ¥300,000 Utilization rate: 100% -2030: Application rate for higher positions: 50% (Application rate) -2030: Rate of “check-in”5 sessions conducted: 100% -2030: Employee enablement score: 100 -2030: Percentage of female managers: Equal to the percentage of female employees (Estimate 38%) -2030: Inclusion is put into practice: 75% or more -2030: Number of employees participating in the Roche Human Resources Exchange Program: Approximately 10% of employees -FY2030 Females in all management positions 30%